Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 56, Issue 2, Pages 274-286Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.114.146290
Keywords
pediatric oncology; positron emission tomography; PET/CT; pediatric cancer imaging; cancer staging; pediatric lymphoma; pediatric sarcoma
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Successful management of solid tumors in children requires imaging tests for accurate disease detection, characterization, and treatment monitoring. Technologic developments aim toward the creation of integrated imaging approaches that provide a comprehensive diagnosis with a single visit. These integrated diagnostic tests not only are convenient for young patients but also save direct and indirect health-care costs by streamlining procedures, minimizing hospitalizations, and minimizing lost school or work time for children and their parents. F-18-FDG PET/CT is a highly sensitive and specific imaging modality for whole-body evaluation of pediatric malignancies. However, recent concerns about ionizing radiation exposure have led to a search for alternative imaging methods, such as whole-body MR imaging and PET/MR. As we develop new approaches for tumor staging, it is important to understand current benchmarks. This review article will synthesize the current literature on F-18-FDG PET/CT for tumor staging in children, summarizing questions that have been solved and providing an outlook on unsolved avenues.
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