Journal
DALTON TRANSACTIONS
Volume 40, Issue 18, Pages 4830-4833Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1dt00020a
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Funding
- NSFC [20971049]
- PCSIRT [IRT0953]
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The fluorescent chelator (FC-1) was designed by combining a metal-chelating unit and a ThT-based A beta aggregate-binding fluorescent unit. FC-1 is a cell membrane-penetrable chelator with a moderate chelation ability to Cu2+ and Zn2+ and can target metal-A beta 40 aggregates. Treatment with FC-1 led to enhanced cytotoxicity of the aggregates, because the aggregates were converted into a pool of oligomers.
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