Journal
DALTON TRANSACTIONS
Volume 40, Issue 10, Pages 2180-2189Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0dt00501k
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Funding
- Hong Kong Research Grants Council [CityU 102109]
- City University of Hong Kong [7002575]
- Hong Kong University Grants Committee [SEG_CityU02]
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Four new luminescent cyclometallated iridium(III) bis(quinolylbenzaldehyde) diimine complexes [Ir(qba)(2)(N<^>N)](PF6) (Hqba = 4-(2-quinolyl)benzaldehyde, N<^>N = 2,2'-bipyridine, bpy (1); 1,10-phenanthroline, phen (2); 3,4,7,8-tetramethyl-1,10-phenanthroline, Me-4-phen (3); 4,7-diphenyl-1,10-phenanthroline, Ph-2-phen (4)) have been synthesised and characterised, and their electronic absorption, emission and electrochemical properties investigated. The X-ray crystal structures of complexes 1 and 2 have been determined. Upon irradiation, complexes 1-4 exhibited intense and long-lived orange-yellow emission in fluid solutions at 298 K and in alcohol glass at 77 K. The emission has been assigned to a triplet intra-ligand ((IL)-I-3) excited state associated with the qba ligand, probably with mixing of some triplet metal-to-ligand charge-transfer ((MLCT)-M-3) (d pi(Ir)->pi*(qba)) character. Reductive amination reactions of complexes 1-4 with the protein bovine serum albumin (BSA) afforded the bioconjugates 1-BSA-4-BSA, respectively. Upon photoexcitation, these bioconjugates displayed intense and long-lived (MLCT)-M-3 (d pi(Ir) -> pi*(N<^>C)) emission in aqueous buffer at 298 K. The cross-linked nature of the Ir-BSA bioconjugates has been verified by SDS-PAGE. Additionally, the cytotoxicity of the complexes towards human cervix epithelioid carcinoma (HeLa) cells has been examined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assays, and the cellular uptake of complex 4 has been investigated by laser-scanning confocal microscopy and flow cytometry.
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