4.7 Article

Fluorescence properties and cellular distribution of the investigational anticancer drug Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex

Journal

DALTON TRANSACTIONS
Volume 39, Issue 3, Pages 704-706

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b919119b

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Funding

  1. FFG (Austrian Research Promotion Agency) [811591]
  2. Austrian Council for Research and Technology Development

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Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), which entered several phase I and II clinical trials as an antitumor chemotherapeutic agent, was found to possess intrinsic fluorescence properties (lambda(ex) = 360 nm), which enabled us to monitor the uptake and intracellular distribution in living human cancer cells by fluorescence microscopy.

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