4.7 Article

Asymmetric general base catalysis of the phospho-aldol reaction via dimeric aluminium hydroxides

Journal

DALTON TRANSACTIONS
Volume 39, Issue 40, Pages 9472-9475

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0dt00459f

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Funding

  1. EPSRC
  2. NSCCS
  3. EPSRC [EP/E013589/1] Funding Source: UKRI
  4. Engineering and Physical Sciences Research Council [EP/E013589/1] Funding Source: researchfish

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Dimeric aluminium hydroxide complexes containing the (R,R)-N,N'-bis(2'-hydroxy-3'-organobenzyl)-trans-1,2-diaminocyclohexane ligand backbone effect catalysis of the phospho-aldol reaction under ambient, aerobic conditions at catalyst loadings of 0.5 mol% to afford enantioselectivities of ca. 65%.

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