Journal
DALTON TRANSACTIONS
Volume 39, Issue 36, Pages 8477-8483Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0dt00239a
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Funding
- European Union [FP6-2003-NEST-B3 15471]
- Marie Curie [MEXT-2004-014320]
- Network of Excellence Idecat [Idecat-CT-2005-011730]
- COST [CM0802]
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The preparation of hybrid transition metalloproteins by thiol-selective incorporation of organometallic rhodium- and ruthenium complexes is described. Phosphine ligands and two rhodium-diphosphine complexes bearing a carboxylic acid group were coupled to the cysteine of PYP R52G, yielding a metalloenzyme active in the rhodium catalyzed hydrogenation of dimethyl itaconate. The successful coupling was shown by P-31 NMR spectroscopy and ESI mass spectroscopy. In addition wild-type PYP (PYP WT), PYP R52G and ALBP were successfully modified with a (eta(6)-arene) ruthenium(II) phenanthroline complex via a maleimide linker.
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