Journal
DALTON TRANSACTIONS
Volume -, Issue 3, Pages 399-414Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b809873p
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Funding
- Ministerio de Educacion y Ciencia de Espana [BFU2005-06758/BMC]
- Generalitat de Catalunya [2005SGR-0028]
- Fundacio La Marato de TV3 [052810]
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In this paper, we review recent DNA-binding agents that are expected to influence the field of DNA-targeting. We restrict ourselves to binders for which the three-dimensional structure in complex with DNA or RNA has been determined by X-ray crystallography or NMR. Furthermore, we primarily focus on unprecedented ways of targeting peculiar DNA structures, such as junctions, quadruplexes, and duplex DNAs different from the B-form. Classical binding modes of small molecular weight compounds to DNA, i.e. groove binding, intercalation and covalent addition are discussed in those cases where the structures represent a novelty. In addition, we review 3D structures of triple-stranded DNA, of the so-called Peptide Nucleic Acids (PNAs), which are oligonucleotide bases linked by a polypeptide backbone, and of aptamers, which are DNA or RNA receptors that are designed combinatorially. A discussion on perspectives in the field of DNA-targeting and on sequence recognition is also provided.
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