Journal
DALTON TRANSACTIONS
Volume -, Issue 16, Pages 2107-2110Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b802806k
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Funding
- Biotechnology and Biological Sciences Research Council [BB/D012694/1] Funding Source: Medline
- Medical Research Council [G0600986, G9439390, G0001237] Funding Source: Medline
- BBSRC [BB/D012694/1] Funding Source: UKRI
- MRC [G9439390, G0600986, G0001237] Funding Source: UKRI
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We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.
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