Journal
DALTON TRANSACTIONS
Volume -, Issue 44, Pages 6159-6164Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b807965j
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Funding
- D.G.I-M.E.C
- FEDER [CTQ 2006-00406/BQU]
- Junta de Castilla y Leon [SA097/A06]
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The present paper describes for the first time an intrinsic fluorescent square-planar platinum(II) complex carrying two ursodeoxycholate ligands ([Pt(UDC)(2)(en)], where UDC- = ursodeoxycholate), that emits at room temperature once free in solution. Kinetic studies were carried out in aqueous solution and in the presence of different NaCl concentrations: 4 mM (similar to cytoplasmic concentration) and 150 mM (similar to plasmatic concentration). This novel compound was synthesized from a [PtCl2(en)] complex and shows increased cytotoxic activity against both resting and cycling HeLa cells, with no toxicity for cell lines derived from neoplastic haematopoietic cells.
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