Journal
CYTOTHERAPY
Volume 15, Issue 5, Pages 525-535Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jcyt.2013.01.003
Keywords
fetal therapy; hematopoietic stem cell transplantation; in utero; tolerance
Ask authors/readers for more resources
In utero hematopoietic stem cell transplantation (IUHCT) is a potential therapeutic alternative to postnatal hematopoietic stem cell transplantation (HSCT) for congenital hematologic disorders that can be diagnosed early in gestation and can be cured by HSCT. The rationale is to take advantage of normal events during hematopoietic and immunologic ontogeny to facilitate allogeneic hematopoietic engraftment. Although the rationale remains compelling, IUHCT has not yet achieved its clinical potential. This review will discuss recent experimental progress toward overcoming the barriers to allogeneic engraftment and new therapeutic strategies that may hasten clinical application.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available