Journal
CYTOTHERAPY
Volume 13, Issue 4, Pages 467-480Publisher
ELSEVIER SCI LTD
DOI: 10.3109/14653249.2010.530651
Keywords
CD34(+); cord blood; cytokines; ex vivo expansion; megakaryocytes; platelet recovery
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Background aims. Expansion of hematopoietic progenitors ex vivo is currently investigated as a means of reducing cytopenia following stem cell transplantation. The principal objective of this study was to develop a new cytokine cocktail that would maximize the expansion of megakaryocyte (Mk) progenitors that could be used to reduce periods of thrombocytopenia. Methods. We measured the individual and synergistic effects of six cytokines [stem cell factor (SCF), FLT-3 ligand (FL), interleukin (IL)-3, IL-6, IL-9 and IL-11] commonly used to expand cord blood (CB) CD34
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