Journal
CYTOTHERAPY
Volume 12, Issue 3, Pages 275-287Publisher
ELSEVIER SCI LTD
DOI: 10.3109/14653241003596679
Keywords
human artery wall; leiomyogenesis; multiorgan donors; multipotent mesenchymal stromal cells
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Background aims. The presence of ectopic tissues in the pathologic artery wall raises the issue of whether multipotent stem cells may reside in the vasculature itself. Recently mesenchymal stromal cells (MSC) have been isolated from different human vascular segments (VW MSC), belying the previous view that the vessel wall is a relatively quiescent tissue. Methods. Resident multipotent cells were recovered from fresh arterial segments (aortic arches, thoracic and femoral arteries) collected in a tissue-banking facility and used to establish an in situ and in vitro study of the stemness features and multipotency of these multidistrict MSC populations. Results. Notch-1
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