Journal
CYTOTHERAPY
Volume 11, Issue 3, Pages 261-267Publisher
ELSEVIER SCI LTD
DOI: 10.1080/14653240902824765
Keywords
Chondrogenesis; development; hypoxia-inducible factor; osteogenesis
Categories
Funding
- National Natural Science Foundation of China [30801164]
- Innovation Program of Shanghai Municipal Education Commission [09YZ107]
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Oxygen availability is a critical signal for the proper development of many tissues. The transcription factor hypoxia-inducible factor (HIF) plays an important role in maintenance of oxygen homeostasis in all metazoans. Numerous growth and transcription factors have been implicated in the development of the skeletal system. Many of the factors that are up-regulated during hypoxia are downstream of HIF activation. Recent work has demonstrated that HIF has a critical function in cartilage and bone development. We summarize current understanding of the role of HIF in bone and cartilage development.
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