Journal
CYTOSKELETON
Volume 69, Issue 10, Pages 778-790Publisher
WILEY-BLACKWELL
DOI: 10.1002/cm.21054
Keywords
cytokinesis; FtsZ/tubulin; FtsA/actin
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Funding
- NIH [GM29764]
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Ancestral homologues of the major eukaryotic cytoskeletal families, tubulin and actin, play critical roles in cytokinesis of bacterial cells. FtsZ is the ancestral homologue of tubulin and assembles into the Z ring that determines the division plane. FtsA, a member of the actin family, is involved in coordinating cell wall synthesis during cytokinesis. FtsA assists in the formation of the Z ring and also has a critical role in recruiting downstream division proteins to the Z ring to generate the divisome that divides the cell. Spatial regulation of cytokinesis occurs at the stage of Z ring assembly and regulation of cell size occurs at this stage or during Z ring maturation. (c) 2012 Wiley Periodicals, Inc
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