Journal
CYTOSKELETON
Volume 68, Issue 11, Pages 596-602Publisher
WILEY
DOI: 10.1002/cm.20543
Keywords
actin; Arp2; 3 complex; cell motility; lamellipodium; electron microscopy; VASP; formin
Categories
Funding
- American Heart Association [11POST5830010]
- Deutsche Forschungsgemeinschaft [BR4116]
- NIH [GM43369, GM063691]
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Membrane protrusion at the leading edge of migrating cells is driven by the polymerization of actin. Recent studies using advanced imaging techniques raised a lively controversy about the morphology of these filaments; however, common ground between the two sides now appears to have been found. Here we discuss how the controversy has led to a deeper consideration of the architecture of actin networks underlying cell migration, and has helped define new challenges that lie ahead. (c) 2011 Wiley Periodicals, Inc.
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