Journal
CYTOMETRY PART A
Volume 81A, Issue 1, Pages 25-34Publisher
WILEY
DOI: 10.1002/cyto.a.21148
Keywords
hierarchical clustering; minimal residual disease; acute lymphoblastic leukemia; support vector machines; multiparameter flow cytometry
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Funding
- JGW Patterson Foundation, UK [BH070348]
- Czech Ministry of Education [MSM0021620813]
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Flow cytometry is a valuable tool in research and diagnostics including minimal residual disease (MRD) monitoring of hematologic malignancies. However, its gradual advancement toward increasing numbers of fluorescent parameters leads to information rich datasets, which are challenging to analyze by standard gating and do not reflect the multidimensionality of the data.
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