Journal
CYTOMETRY PART A
Volume 79A, Issue 1, Pages 77-83Publisher
WILEY
DOI: 10.1002/cyto.a.20963
Keywords
proline-rich peptide from Bothrops jararaca; Bj-PRO-7a; muscarinic receptor; M1 agonist
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico), Brazil [2006/61285-9]
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Proline-rich peptides from Bothrops jararaca venom (Bj-PRO) were characterized based on the capability to inhibit the somatic angiotensin-converting enzyme. The pharmacological action of these peptides resulted in the development of Captopril, one of the best examples of a target-driven drug discovery for treatment of hypertension. However, biochemical and biological properties of Bj-PROs were not completely elucidated yet, and many recent studies have suggested that their activity relies on angiotensin-converting enzyme-independent mechanisms. Here, we show that Bj-PRO-7a (
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