Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 25, Issue 2, Pages 107-113Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2014.01.001
Keywords
BLyS; BAFF; TACI; Germinal center
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Funding
- NIAID NIH HHS [P30 AI045008, R01 AI073939, R01 AI054488, T32 AI055428] Funding Source: Medline
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BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity maturation in germinal centers, which lie at the intersection of the pre-immune and antigen-experienced B cell compartments. We propose a model whereby tolerogenic selection at the transitional stage and affinity maturation in the germinal center employ the same BLyS driven mechanism. (C) 2014 Elsevier Ltd. All rights reserved.
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