Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 25, Issue 6, Pages 631-639Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2014.05.003
Keywords
MITA; cGAMP; Innate immune response; DNA sensor
Categories
Funding
- Chinese Ministry of Science and Technology [2014CB542603, 2012CB910201]
- National Natural Science Foundation of China [31170792, 31270932, 31130020, 31321001]
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The recognition of nucleic acids is a general strategy used by the host to detect invading pathogens. Many studies have established that MITA/STING is a central component in the innate immune response to cytosolic DNA and RNA derived from pathogens. MITA can act both as a direct sensor of cyclic dinucleotides (CDNs) and as an adaptor for the recruitment of downstream signaling components. In both roles, MITA is part of signaling cascades that orchestrate innate immune defenses against various pathogens, including viruses, bacteria and parasites. Here, we highlight recent studies that have uncovered the molecular mechanisms of MITA-mediated signal transduction and regulation, and discuss some notable issues that remain elusive. (C) 2014 Elsevier Ltd. All rights reserved.
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