Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 25, Issue 4, Pages 443-451Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2014.07.008
Keywords
Psoriasis; Atopic dermatitis; Antimicrobial peptides; Microbiome; Pruritus; Keratinocytes
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Funding
- British Skin Foundation [5035s]
- Deutsche Forschungsgemeinschaft (DFG)
- German Ministry for Research and Education (BMBF)
- National Institute for Health Research (NIHR)
- British Skin Foundation [5035s] Funding Source: researchfish
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This review focuses on treatment targets for the most common inflammatory skin diseases, eczema and psoriasis with an emphasis on cytokines expressed in the uppermost layer of the skin which is easily accessible for diagnostic and therapeutic approaches. Recently, a significant body of research has highlighted the influence of the skin barrier and the patients' microbiome on skin inflammatory responses and we will comment on their impact on mediator regulation. Itch is a prominent dermatology symptom which is influenced by cytokines and can via itch-scratch cycle impact on the skin barrier and mediator expression associated with damage. Taking the contribution of pruritus and superficial skin damage into account, we address cytokines as targets for stratified treatment approaches in subgroups of eczema and psoriasis. (C) 2014 Elsevier Ltd. All rights reserved.
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