Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 24, Issue 4, Pages 311-318Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2013.05.001
Keywords
Anthracyclines; Apoptosis; ATP; Calcium; Calreticulin; PERK
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Funding
- Ligue Nationale contre le Cancer (Equipes labellisees)
- SIRIC Socrates
- Agence Nationale pour la Recherche (ANR AUTOPH, ANR Emergence)
- European Commission (ArtForce)
- European Research Council
- Fondation pour la Recherche Medicale (FRM)
- Institut National du Cancer (INCa)
- Fondation de France
- Canceropole Ile-de-France, Fondation Bettencourt-Schueller
- LabEx Immuno-Oncology
- Paris Alliance of Cancer Research Institutes
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Preclinical and clinical findings suggest that tumor-specific immune responses may be responsible - at least in part for the clinical success of therapeutic regimens that rely on immunogenic cell death (ICD) inducers, including anthracyclines and oxaliplatin. The molecular pathways whereby some, but not all, cytotoxic agents promote bona fide ICD remain to be fully elucidated. Nevertheless, a central role for the endoplasmic reticulum (ER) stress response has been revealed in all scenarios of ICD described thus far. Hence, components of the ER stress machinery may constitute clinically relevant druggable targets for the induction of ICD. In this review, we will summarize recent findings in the field of ICD research with a special focus on ER stress mechanisms and their implication for cancer therapy. (C) 2013 Elsevier Ltd. All rights reserved.
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