Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 24, Issue 3, Pages 203-215Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2013.04.003
Keywords
A proliferation inducing ligand (APRIL); Autoimmunity; B cell activating factor from the tumor necrosis factor family (TNF) (BAFF); Cancer; Systemic lupus eiythematosus (SLE)
Categories
Ask authors/readers for more resources
The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials. (C) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available