Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 24, Issue 4, Pages 345-353Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2013.01.001
Keywords
Adult T cell leukemia; Biomarker; Inflammation; Redoxisome; Thioredoxin
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Funding
- World Class University through the Ewha Womans University [R31-10010]
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The manipulation of cellular redox status has emerged as a promising therapeutic strategy to prevent uncontrolled inflammatory response. Thioredoxin is an important regulator of cellular redox homeostasis, which catalyzes the reduction of disulfide bonds. Human thioredoxin, originally identified as a secretory protein ADF, has been implicated in a wide variety of redox regulations in both intracellular and extracellular compartments. This review includes a summary of the evidence available supporting the employment of the beneficial properties of thioredoxin to combat inflammation, an evaluation of the potential of redox-based therapy for the treatment of inflammatory diseases, and a discussion on the conceptual model of a redox-sensitive signaling complex, Redoxisome, consisting of thioredoxin and its redox partners. (C) 2013 Elsevier Ltd. All rights reserved.
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