Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 24, Issue 6, Pages 571-577Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2013.07.001
Keywords
Interleukin-27; HIV; Cytokines; SPTBN1; Therapy
Categories
Funding
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
- National Institute of Allergy and Infectious Disease
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Interleukin 27 (IL-27) is an immunomodulatory cytokine with important roles in both the innate and adaptive immune systems. In the last five years, the addition of exogenous IL-27 to primary cell cultures has been demonstrated to decrease HIV-1 replication in a number of cell types including peripheral blood mononuclear cells (PBMCs), CD4+ T cells, macrophages and dendritic cells. These in vitro findings suggest that IL-27 may have therapeutic value in the setting of HIV-1 infection. In this review, we describe the current knowledge of the biology of IL-27, its effects primarily on HIV-1 replication but also in other viral infections and explore its potential role as a therapeutic cytokine for the treatment of patients with HIV-1 infection. (C) 2013 Elsevier Ltd. All rights reserved.
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