Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 23, Issue 3, Pages 109-118Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2012.04.002
Keywords
TNIP1; ABIN-1; TNF alpha receptor; Nuclear receptor; Inflammation
Categories
Funding
- National Institutes of Health (NIAMS) [AR048660]
- Boehringer-Ingelheim Pharmaceuticals
- American Foundation for Pharmaceutical Education
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A vast number of cellular processes and signaling pathways are regulated by various receptors, ranging from transmembrane to nuclear receptors. These receptor-mediated processes are modulated by a diverse set of regulatory proteins. TNF alpha-induced protein 3-interacting protein 1 is such a protein that inhibits both transduction by transmembrane receptors, such as TNF alpha-receptor, EGF-R, and TLR, and nuclear receptors' PPAR and RAR activity. These receptors play key roles in regulating inflammation and inflammatory diseases. A growing number of references have implicated TNIP1 through GWAS and expression studies in chronic inflammatory diseases such as psoriasis and rheumatoid arthritis, although TNIP1s exact role has yet been determined. In this review, we aim to integrate the current knowledge of TNIP1s functions with the diseases in which it has been associated to potentially elucidate the role this regulator has in promoting or alleviating these inflammatory diseases. (C) 2012 Elsevier Ltd. All rights reserved.
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