Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 23, Issue 6, Pages 357-365Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2012.06.004
Keywords
Neurotrophins; Breast cancer; Tumor growth and metastasis; Biomarkers; Therapeutic targets
Categories
Funding
- University of Newcastle, Australia
Ask authors/readers for more resources
Growth factors of the neurotrophin family and their receptors have been mainly studied in the nervous system, but they are also expressed in carcinomas, and in breast cancer they significantly impact tumor cell growth and metastasis through various signaling pathways. Nerve growth factor and its precursor proNGF, brain-derived neurotrophic factor and neurotrophin-4/5 stimulate breast cancer cells through an autocrine loop involving the tyrosine kinase receptors TrkA, TrkB as well as its truncated form TrkB.T1 and the p75(NTR) death receptor. Preclinical studies have shown that targeting neurotrophins and their receptors induce an inhibition of breast cancer cell survival, proliferation and invasion. Furthermore, targeting neurotrophins may also decrease tumor-induced cancer pain and this additional effect further strengthens their clinical relevance. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available