Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 22, Issue 1, Pages 35-43Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2011.01.001
Keywords
IFN-gamma; Hepatocyte; Liver; Proliferation; Apoptosis
Categories
Funding
- National Center for Research Resources, National Institutes of Health [P20RR016454]
- National Institute of Diabetes and Digestive and Kidney Diseases [R15DK088749]
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Interferon (IFN)-gamma is a cytokine known for its immunomodulatory and anti-proliferative action. In the liver, IFN-gamma can induce hepatocyte apoptosis or inhibit hepatocyte cell cycle progression. This article reviews recent mechanistic reports that describe how IFN-gamma may direct the fate of hepatocytes either towards apoptosis or a cell cycle arrest. This review also describes a probable role for IFN-gamma in modulating hepatocyte fate during liver regeneration, transplantation, hepatitis, fibrosis and hepatocellular carcinoma, and highlights promising areas of research that may lead to the development of IFN-gamma as a therapy to enhance recovery from liver disease. (C) 2011 Elsevier Ltd. All rights reserved.
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