Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 22, Issue 5-6, Pages 345-358Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2011.09.002
Keywords
Angiogenesis; Chemokine; Colorectal cancer; Leukocyte
Categories
Funding
- Regional Government of Flanders
- Fund for Scientific Research of Flanders (F.W.O.-Vlaanderen)
- Belgian Science Policy
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Cancer is a life-threatening disease world-wide and colorectal cancer is the second common cause of cancer mortality. The interaction between tumor cells and stromal cells plays a crucial role in tumor initiation and progression and is partially mediated by chemokines. Chemokines predominantly participate in the chemoattraction of leukocytes to inflammatory sites. Nowadays, it is clear that CXC chemokines and their receptors (CXCR) may also modulate tumor behavior by several important mechanisms: regulation of angiogenesis, activation of a tumor-specific immune response by attracting leukocytes, stimulation of tumor cell proliferation and metastasis. Here, we review the expression and complex roles of CXC chemokines (CXCL1 to CXCL16) and their receptors (CXCR1 to CXCR6) in colorectal cancer. Overall, increased expression levels of CXC chemokines correlate with poor prognosis. (C) 2011 Elsevier Ltd. All rights reserved.
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