Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 22, Issue 1, Pages 19-33Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2010.09.003
Keywords
IL-15; Immune system; Autoimmune diseases; Infectious diseases; Immune-therapeutic tool
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IL-15 has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. However, IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Therefore, targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. On the other hand, in some infectious diseases, IL-15 production is compromised but IL-15 given exogenously can potentially enhance immune responses to pathogens. Here, we discuss the current understanding of IL-15 role in immune-mediated and infectious diseases as well as its therapeutic use. (C) 2010 Elsevier Ltd. All rights reserved.
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