Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 22, Issue 5-6, Pages 277-286Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2011.11.002
Keywords
TNF; NF-kappa B; Ubiquitin; A20; Immunity
Categories
Funding
- Interuniversity Attraction Poles [IAP6/18]
- Fund for Scientific Research (FWO)-Flanders [G.0619.10, G.0089.10, 3G023611]
- Foundation Against Cancer
- IWT
- Queen Elisabeth Medical Foundation
- 'Hercules' and 'Group-ID MRP' initiatives of Ghent University
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TNF is a multifunctional cytokine that plays a key role in innate immunity by inducing the expression of a variety of genes that are involved in an inflammatory response. TNF-induced NF-kappa B activation is one of the best studied signaling pathways in mammalian cells and has recently led to a revival of research in the biology of ubiquitin. Many NF-kappa B signaling proteins are modified by specific ubiquitin ligases with different types of ubiquitin chains that are recognized by other proteins and which determine the outcome of ubiquitination. In addition, specific de-ubiquitinases make the whole process reversible. This review summarizes recent findings that have shaped our current understanding on the role of cytoplasmic ubiquitination events in the regulation of TNF-induced NF-kappa B signaling. (C) 2011 Elsevier Ltd. All rights reserved.
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