Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 21, Issue 4, Pages 275-286Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2010.04.003
Keywords
TNF; Nuclear receptors; Crosstalk; Steroids
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Funding
- Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen)
- Research Council of Ghent University
- Research Foundation Flanders (FWO Vlaanderen)
- Inter-university Attraction Poles Program of the Belgian Science Policy
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TNF is a Janus-faced protein. It possesses impressive anti-tumor activities, but it is also one of the strongest known pro-inflammatory cytokines, which hampers its use as a systemic anti-cancer agent. TNF has been shown to play a detrimental role in inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Glucocorticoids are strongly anti-inflammatory and exert their therapeutic effects through binding to their receptor, the glucocorticoid receptor. Therefore, glucocorticoids have been used for over half a century for the treatment of inflammatory diseases. However, many patients are or become resistant to the therapeutic effects of glucocorticoids. Inflammatory cytokines have been suggested to play an important role in this steroid insensitivity or glucocorticoid resistance. This review aims to highlight the mechanisms of mutual inhibition between TNF and GR signaling pathways. (C) 2010 Elsevier Ltd. All rights reserved.
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