Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 21, Issue 5, Pages 365-379Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2010.08.002
Keywords
Class II cytokine; Cytokine receptor; Psoriasis; Innate immunity; Tissue damage; Antimicrobial protein
Categories
Funding
- Deutsche Forschungsgemeinschaft (German Research Foundation) [SA 1868/2-1]
Ask authors/readers for more resources
Interleukin (IL)-22 is a member of the IL-10 cytokine family that is produced by special immune cell populations, including Th22, Th1, and Th17 cells, classical and non-classical (NK-22) NK cells, NKT cells, and lymphoid tissue inducer cells. This cytokine does not influence cells of the hematopoietic lineage. Instead, its target cells are certain tissue cells from the skin, liver and kidney, and from organs of the respiratory and gastrointestinal systems. The main biological role of IL-22 includes the increase of innate immunity, protection from damage, and enhancement of regeneration. IL-22 can play either a protective or a pathogenic role in chronic inflammatory diseases depending on the nature of the affected tissue and the local cytokine milieu. This review highlights the primary effects of IL-22 on its target cells, its role in the defense against infections, in tumorigenesis, in inflammatory diseases and allergy as well as the potential of the therapeutic modulation of IL-22 action. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available