Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 21, Issue 4, Pages 287-298Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2010.06.001
Keywords
Bone morphogenetic protein; BMP; Signaling; Vasculature; Development; Disease
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Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis and disease in the adult. However, discrepancies between in vitro and in Vivo findings and distinct functional properties of the BMP signaling pathway in different vascular beds, have led to controversies in the field that have been difficult to reconcile. This review attempts to clarify some of these issues by providing an up to date overview of the biology and genetics of BMP signaling relevant to the intact vasculature. (C) 2010 Elsevier Ltd. All rights reserved.
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