Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 20, Issue 2, Pages 125-135Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2008.11.003
Keywords
Atherosclerosis; Interferon-gamma; Foam cell formation; T(h)1 immune response
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Funding
- British Heart Foundation [PG/07/031/22716]
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Atherosclerosis is a chronic inflammatory disease that is characterized by the development of fibrotic plaques in the arterial wall. The disease exhibits a complex aetiology and its progression is influenced by a number of environmental and genetic risk factors. The cytokine interferon-gamma (IFN-gamma), a key regulator of immune function, is highly expressed in atherosclerotic lesions and has emerged as a significant factor in atherogenesis. Evidence from both mouse models of atherosclerosis and in vitro cell culture has suggested that the role of IFN-gamma is complex since both pro- and anti-atherogenic actions have been affiliated to it. This review will focus on evaluating the contribution of IFN-gamma to atherosclerosis and, in particular, how it regulates immune responses to the disease. (C) 2008 Elsevier Ltd. All rights reserved.
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