Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 20, Issue 5-6, Pages 475-480Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2009.10.018
Keywords
BMP; Endochondral ossification; Fracture healing; Bone regeneration
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BMPs are best known for their actions as bone formation signals. Recent studies using transgenic mice in which individual osteogenic BMPs have been removed from the limb skeleton have identified BMP2 as a fundamental component of the inherent regenerative capacity of bone. This review summarizes current findings on the specific requirement for BMP2 in bone formation and repair. (C) 2009 Elsevier Ltd. All rights reserved.
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