Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 19, Issue 3-4, Pages 199-207Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2008.04.002
Keywords
TRAF; B lymphocyte; signal transducers; humoral immune responses; CD40
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Funding
- NATIONAL CANCER INSTITUTE [R01CA099997] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI049993, R01AI028847] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA099997-03, R01 CA099997] Funding Source: Medline
- NIAID NIH HHS [R01 AI028847-16A1, R01 AI028847, R01 AI049993, R01 AI049993-06] Funding Source: Medline
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Tumor necrosis factor receptor associated factors (TRAFs) play a variety of interesting and important roles in the regulation of B lymphocyte function. They act both as cytoplasmic regulatory molecules, and as signal transducers for receptors involved in both innate and adaptive Immoral immune responses. In this brief review, we highlight the current state of knowledge of the diverse roles of TRAF molecules in the functions of B lymphocytes. (c) 2008 Elsevier Ltd. All rights reserved.
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