Journal
CYTOKINE
Volume 70, Issue 2, Pages 185-193Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2014.06.019
Keywords
Osteoarthritis; Pain; Chemokines; Cytokines; Animal models
Funding
- Arthritis Foundation Post-Doctoral Fellowship
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases [F32AR062927, R01AR064251]
- [2 R01 DA013141]
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Osteoarthritis is a chronic and painful disease of synovial joints. Chondrocytes, synovial cells and other cells in the joint can express and respond to cytokines and chemokines, and all of these molecules can also be detected in synovial fluid of patients with osteoarthritis. The presence of inflammatory cytokines in the osteoarthritic joint raises the question whether they may directly participate in pain generation by acting on innervating joint nociceptors. Here, we first provide a systematic discussion of the known proalgesic effects of cytokines and chemokines that have been detected in osteoarthritic joints, including TNF-alpha, IL-1, IL-6, IL-15, IL-10, and the chemokines, MCP-1 and fractalkine. Subsequently, we discuss what is known about their contribution to joint pain based on studies in animal models. Finally, we briefly discuss limited data available from clinical studies in human osteoarthritis. (C) 2014 Elsevier Ltd. All rights reserved.
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