Journal
CYTOKINE
Volume 64, Issue 2, Pages 477-485Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2013.07.022
Keywords
Interleukin 17; IL-17R; Signaling transduction; Act1
Funding
- NHLBI NIH HHS [R01 HL098935, U10 HL109250, P01 HL103453] Funding Source: Medline
- NIAID NIH HHS [T32 AI089474] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007250] Funding Source: Medline
- NINDS NIH HHS [R01 NS071996] Funding Source: Medline
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The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. Although IL-17A is the signature cytokine produced by T helper 17 (Th17) cells, IL-17A and other IL-17 family cytokines have multiple sources ranging from immune cells to non-immune cells. The IL-17 family signals via their correspondent receptors and activates downstream pathways that include NF kappa B, MAPKs and C/EBPs to induce the expression of anti-microbial peptides, cytokines and chemokines. The proximal adaptor Act1 is a common mediator during the signaling of all IL-17 cytokines so far and is thus involved in IL-17 mediated host defense and IL-17-driven autoimmune conditions. This review will give an overview and recent updates on the IL-17 family, the activation and regulation of IL-17 signaling as well as diseases associated with this cytokine family. (C) 2013 Elsevier Ltd. All rights reserved.
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