Journal
CYTOKINE
Volume 50, Issue 1, Pages 42-49Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2009.12.010
Keywords
CK beta 8; CK beta 8-1; Cell cycle; Cyclin; Signal transduction
Funding
- National Research Foundation of Korea (NRF) [20090084184]
- Ministry of Education, Science and Technology, Republic of Korea
- National R&D Program for Cancer Control, Ministry for Health, Welfare and Family affairs, Republic of Korea [0720480]
- Korea Health Promotion Institute [0720480] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2007-2004277] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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CK beta 8/CCL23 is a CC chemokine and alternative splicing of the CK beta 8 gene produces two mRNAs that encode CK beta 8 and its isoform CK beta 8-1. Chemokines play a critical role in leukocyte trafficking and development of inflammation and chemokines are also known to be involved in cell proliferation. To investigate participation of CK beta 8 and CK beta 8-1 in cell proliferation, we examined the effects of CK beta 8 and CK beta 8-1 in the cell cycle. Both CK beta 8 and CK beta 8-1 induced cell-cycle progression. We next investigated whether MAPKs are involved in CK beta 8- and CK beta 8-1-induced cell proliferation. CK beta 8- and CK beta 8-1-stimulated cells showed phosphorylation of ERK1/2 and an inhibitor study indicated that CK beta 8- and CK beta 8-1-induced activation of ERK1/2 is mediated by the G(i)/G(o) protein, PLC, and PKC delta. CK beta 8 and CK beta 8-1 regulated expression of the cell cycle regulators cyclin D-3 and cyclin B-1, and the immediate early response gene products c-Myc and Egr-1. These results indicate that both CK beta 8 and CK beta 8-1 are involved in cell proliferation by modulating the cell cycle regulators. (C) 2009 Elsevier Ltd. All rights reserved.
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