Journal
CYTOKINE
Volume 42, Issue 2, Pages 145-151Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2008.01.006
Keywords
toll-like receptor; LPS; proinflammatory cytokines; MyD88; TRIF
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The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway. (C) 2008 Elsevier Ltd. All rights reserved.
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