Journal
CYTOGENETIC AND GENOME RESEARCH
Volume 133, Issue 2-4, Pages 234-242Publisher
KARGER
DOI: 10.1159/000323793
Keywords
Chromosome Segregation; Cohesin; Meiosis; PP2A; Separase; Shugoshin
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Funding
- Wellcome Trust
- Scottish Universities Life Sciences Alliance (SULSA)
- EMBO
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During meiosis, DNA replication is followed by 2 successive chromosome segregation events, resulting in the production of gametes with a haploid number of chromosomes from a diploid precursor cell. Faithful chromosome segregation in meiosis requires that sister chromatid cohesion is lost from chromosome arms during meiosis I, but retained at centromeric regions until meiosis II. Recent studies have begun to uncover the mechanisms underlying this stepwise loss of cohesion in meiosis and the role of a conserved protein, shugoshin, in regulating this process. Copyright (C) 2011 S. Karger AG, Basel
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