Journal
CYTOGENETIC AND GENOME RESEARCH
Volume 123, Issue 1-4, Pages 156-160Publisher
KARGER
DOI: 10.1159/000184703
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Funding
- Ministry of Health, Labor and Welfare, Japan
- Japan Health Science Foundation
- program of Founding Research Centers for Emerging and Reemerging Infection Disease
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan
- Department of Biotechnology (DBT)
- Ministry of Science and Technology, Govt of India
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Variations of gene copy number in the human genome are increasingly recognized as a genetic factor in phenotypic variation. Human CC chemokine ligand 3-like 1 gene (CCL3L1), which is located on human chromosome 17q11.2, is highly variable in copy number owing to having a hot spot for segmental duplications. CCL3L1, a natural ligand for HIV-1 co-receptor CCR5, is a potent HIV-1-suppressive chemokine. CCL3L1 copy number variation (CNV) is tightly linked to HIV-1/AIDS susceptibility, and a lower copy number is associated with an enhanced risk for acquiring HIV-1 and also progressing more rapidly to AIDS and death. In this article we review recent studies to evaluate the association between the CCL3L1 copy number and HIV-1/AIDS susceptibility. Copyright (C) 2009 S. Karger AG, Basel
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