Journal
CUTANEOUS AND OCULAR TOXICOLOGY
Volume 28, Issue 1, Pages 45-47Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/15569520802696250
Keywords
Sulfasalazine; drug-induced hypersensitivity syndrome; human herpesvirus-6 reactivation
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Drug-induced hypersensitivity syndrome (DINS) is characterized by high fever, facial edema, diffuse maculopapular eruption, and multiorgan involvement. Human herpesvirus (HHV)-6 reactivation is an accepted criterion for the diagnosis of DINS and has prognostic importance. We report a 15-year-old boy with juvenile rheumatoid arthritis who developed DINS due to sulfasalazine, associated with reactivation of HHV-6.
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