Journal
CURRENT VASCULAR PHARMACOLOGY
Volume 10, Issue 3, Pages 285-288Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157016112799959369
Keywords
Angiogenesis; neurogenesis; stroke; neural stem cells; CD34-positive cells
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Cell-based therapies are a novel approach for regeneration of microvasculature. We have shown that administration of CD34-positive cells, the rich cell fraction of endothelial progenitor cells, after stroke induces angiogenesis that results in enhanced endogenous neurogenesis and functional recovery in a murine model. Moreover, injury-induced neurogenesis occurs in the human brain following a stroke during the acute to sub-acute period. Based on these observations, clinical trials of cell therapies that aim to regenerate micro-circulation in the brain following a stroke are ongoing worldwide. This review summarizes the current basic research findings about the link between angiogenesis and neurogenesis in the post-stroke brain and introduces the ongoing clinical trials of cell-based therapies for patients that have suffered a stroke.
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