Journal
CURRENT VASCULAR PHARMACOLOGY
Volume 8, Issue 2, Pages 233-248Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157016110790886983
Keywords
Innate immunity; inflammation; macrophage; activation; M1 M2; polarization
Funding
- Netherlands Heart Foundation [2005B175, 2007T067]
- Netherlands Organisation for Scientific Research [Vidi 016-066-329]
- European Union [MEST-CT-2005-020706/CADRE2]
- Netherlands Heart Foundation
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Atherosclerosis is a chronic inflammatory disease involving many cell types with a well-accepted key role for macrophages. A wide array of different properties and functional characteristics are attributed to macrophages present in the atherosclerotic plaque. As an increasing body of evidence strengthens the consensus that macrophages comprise a heterogeneous population, several co-existing subtypes with diverse, even opposing specialties have already been described in fields like parasitology, tumour biology and metabolic disorders. However, macrophage heterogeneity within atherosclerotic lesions has not been studied in detail yet. In this review we will introduce the characteristics of macrophage subsets in other pathologies and address the presence and possible roles of distinct macrophage subtypes in the rapidly evolving field of atherosclerosis. Finally, we make an effort to relate these subtypes to disease progression and explore a number of opportunities for novel diagnostic and therapeutic approaches.
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