Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 18, Issue 10, Pages 857-880Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026618666180608125344
Keywords
Chemotherapy; multi-drug resistance; anthracyclines; doxorubicin; nano-carriers; ultrasound
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Funding
- AUS Faculty Research Grants
- Patient's Friends Committee-Sharjah
- AlJalila Foundation
- Al Qasimi Foundation
- Dana Gas Endowed Chair for Chemical Engineering
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Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.
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