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Ferroquine as an Oxidative Shock Antimalarial

Journal

CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 14, Issue 14, Pages 1684-1692

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026614666140808122329

Keywords

Malaria; ferroquine; mechanism of action; hydrogen bond; redox behavior

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Over the course of the development of the antimalarial ferroquine, we have developed many ideas about its specific mechanism of action. Those ideas have enabled us to propose several experiments to control the validity of these hypotheses concerning differences between ferroquine and chloroquine and their respective mechanisms of action. We have now established an ultimate theory reconciling the hydrogen bond and the redox mechanisms hypotheses of ferroquine and fitting a wider range of published experimental results.

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