Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 14, Issue 21, Pages 2388-2397Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026615666141208100411
Keywords
Chemical synthesis; Gemini analogs; Steroid; Vitamin D
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Funding
- Xunta de Galicia [N EXPTE. CN 2012/184]
- European Social Fund
- state budget of the Czech Republic [CZ.1.07/2.3.00/30.0004]
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The Gemini analogs are the last significant contribution to the family of vitamin D derivatives in medicine, for the treatment of cancer. The first Gemini analog was characterized by two symmetric side chains at C-20. Following numerous modifications, the most active analog bears a C-23-triple bond, C-26, 27-hexafluoro substituents on one side chain and a terminal trideuteromethylhydroxy group on the other side chain. This progression was possible due to improvements in the synthetic methods for the preparation of these derivatives, which allowed for increasing molecular complexity and complete diastereoselective control at C-20 and the substituted sidechains.
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