Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 14, Issue 10, Pages 1225-1234Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026614666140423101226
Keywords
beta-Peptides; conformational analysis; molecular dynamics; nuclear magnetic resonance
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Funding
- Ministerio de Economia y Competitividad
- FEDER [CTQ2012-36365]
- CESGA (Spain)
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alpha-Methylisoserine, a chiral acyclic quaternary beta-amino acid, has been used to mimic secondary structures, when it is incorporated in a homogeneous beta(2,2)-dipeptide. In particular, the observed folded conformations in aqueous solution can be regarded as mimics of beta-turn.
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