Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 12, Issue 20, Pages 2240-2257Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802612805220057
Keywords
Alzheimer's disease; antidepressant agents; isocarboxazid; monoamine oxidase; parkinson's disease; pyrazoline
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Funding
- MIUR (Italy)
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Among different heterocyclic chemotypes incorporating two nitrogen atoms, pyrazolines could be considered a valid pharmacophore for the synthesis of selective monoamine oxidase (MAO) inhibitors because they were developed by the cyclization of the early hydrazine derivatives such as isocarboxazid. Substituted pyrazolines, decorated with different functional groups, are important lead compounds endowed with a large amount of biological activities. As a matter of this, most of them were also evaluated as dual inhibitors with a synergistic action towards different classes of enzymes (ciclooxygenase, acetylcholinesterase, butyrylcholinesterase). Moreover due to the direct correlation with the recognized MAO inhibition, this scaffold displayed antidepressant and anticonvulsant properties in animal models.
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